What performance does the HPE P40486-B21 deliver?

Provides 700,000 random 4KB read IOPS and 90,000 random 4KB write IOPS via PCIe 4.0 x4 NVMe interface. Optimized for mixed use workloads with 3 DWPD endurance, suitable for virtualization and databases in HPE ProLiant servers.

Is this SSD compatible with older HPE servers?

Yes, U.3 interface is 100% backward compatible with NVMe U.2 backplanes on HPE Gen10 servers, operating at Gen3 speeds if needed. Full Gen4 performance on Gen10 Plus and later ProLiant DL/ML rack platforms.

What is the endurance rating of this drive?

Rated for 3 Drive Writes Per Day (DWPD) mixed use over 5 years, equating to approximately 1,600TBW total. TLC NAND with enterprise error correction supports sustained write workloads in production environments.

Does it include a carrier for HPE servers?

Includes HPE Basic Carrier (BC) for 2.5-inch SFF bays, hot-pluggable design. Standard for ProLiant servers enabling tool-less installation and LED status monitoring.

What workloads is this SSD optimized for?

Mainstream mixed use applications including read caching, social media analytics, bulk storage, email servers, and boot volumes. Balances high read IOPS with write endurance for general enterprise server duties.

Is the firmware secure and signed?

Yes, features digitally signed firmware (DS) with full data-path protection. Prevents unauthorized modifications and ensures boot integrity in secure server environments.

P40486-B21 - HPE P40486-B21 800GB NVMe Gen4 MU U.3 SFF Enterprise SSD

Name: HPE P40486-B21 800GB NVMe Gen4 MU U.3 SFF Enterprise SSD
Brand: HPE
SKU: P40486-B21

P40486-B21 - HPE P40486-B21 800GB NVMe Gen4 MU U.3 SFF Enterprise SSD | US IT Hardware

Product overview

The HPE P40486-B21 is an 800GB NVMe Gen4 Mainstream Performance Mixed Use Solid State Drive designed for enterprise server environments requiring balanced read/write performance and high endurance. Featuring PCIe 4.0 x4 U.3 interface in a 2.5-inch SFF form factor with Basic Carrier (BC), it delivers up to 700,000 random 4KB read IOPS and 90,000 random 4KB write IOPS, making it suitable for mixed workloads including virtualization, databases, and analytics. With 3 Drive Writes Per Day (DWPD) endurance rating, it supports sustained write-intensive operations typical in enterprise data centers. The drive includes full data-path error detection for data integrity and is hot-pluggable for seamless maintenance. Backward compatible with NVMe U.2 backplanes on HPE Gen10 servers, it enhances performance in ProLiant DL/ML rack servers. Optimized for read caching, bulk storage, and boot volumes, this TLC-based SSD from the CD6 series provides exceptional reliability with power efficiency. Ideal for HPE ProLiant servers, it reduces latency and boosts IOPS over SATA/SAS alternatives, improving ROI through higher density and faster business results in mission-critical applications.

800GB NVMe PCIe Gen4 U.3 MU SSD.
700K read / 90K write 4KB IOPS.
3 DWPD mixed use endurance rating.
2.5in SFF BC hot-pluggable.
HPE ProLiant Gen10+ compatible.
TLC flash w/ full data protection.

Expedited and overnight shipping options are available at checkout, priced by destination and service.
Purchase orders accepted from qualified institutions.
Refunds within 14 days and replacements within 30 days of delivery with an RMA (25% restocking fee on customer-initiated returns), and every part carries our Standard 30-Day Warranty - see our return policy or contact US IT Hardware.

Featuring

Manufacturer part #	P40486-B21
Brand	HPE
Condition	New
Model	800GB NVMe Gen4 Mainstream Performance Mixed Use SFF BC U.3
Drive Type	Internal hot-plug
Product Line	CD6
Product Type	Solid State Drive - NVMe Mixed Use
Wireless LAN	No
Compatibility	HPE ProLiant Gen10 Plus and later rack servers
Drive Carrier	HPE Basic Carrier (BC)
Hot Pluggable	Yes

Compatible systems

Optimized for HPE ProLiant Gen10+ servers with NVMe backplanes. Native OS support across major hypervisors and enterprise Linux.

HPE ProLiant
Model: DL380
Form factor: 2U Rack
Generation: Gen10 Plus
Full Gen4 support with latest firmware
HPE ProLiant
Model: DL360
Form factor: 1U Rack
Generation: Gen10 Plus
U.3 backplanes required
HPE ProLiant
Model: ML350
Form factor: Tower/Rack
Generation: Gen10
Gen3 speeds on U.2 compatible

Best for

Virtualization
VMware vSphere and Hyper-V hosts with multiple VMs requiring consistent low-latency I/O and mixed read/write patterns across virtualized workloads.
Database Servers
OLTP databases like SQL Server, Oracle, PostgreSQL handling high transaction volumes with 700K read IOPS and 3 DWPD mixed use endurance.
Big Data Analytics
Hadoop, Spark clusters processing large datasets with balanced sequential/random performance in enterprise analytics environments.

Details

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NVMe Enterprise & Data Center SSDs 800GB Enterprise SSDs HPE Enterprise SSDs 2.5-inch Enterprise SSDs

Flash Type	TLC
Random Read IOPS	700,000 (4KB)
Storage Capacity	800 GB
Random Write IOPS	90,000 (4KB)

Height	15 mm
Weight	500 g (approximate)
Form Factor	2.5-inch SFF

Port	Dual Port capable
Drive Interface	U.3 PCIe NVMe 4.0 x4

HPE P40486-B21 800GB NVMe Gen4 MU U.3 SFF Enterprise SSD

Product overview

Featuring

Compatible systems

Best for

Details

Shipping, warranty & returns

Customer reviews

Storage

Physical Characteristics

Environmental

Interface/Ports

Frequently asked questions

HPE P40486-B21 800GB NVMe Gen4 MU U.3 SFF Enterprise SSD

Product overview

Featuring

Compatible systems

Best for

Details

Shipping, warranty & returns

Customer reviews

Shop these collections

Storage

Physical Characteristics

Environmental

Interface/Ports

Frequently asked questions